Co-Design Approaches to Preventing Cardiovascular Disease Among Aboriginal and Torres Strait Islander Women

Selective Macrocyclic WEE1 Kinase Inhibitors with Strong Efficacy against Patient-Derived Colorectal Cancer Organoids

JL Syphers, JA Wright, A Kumar, N To, L Elson, A Krämer, S Müller, V Morasch, A Chang, S Young, EK Sloan, R de Nys, TN Silva, L Vrbanac, KR Barratt, J Leeflang, ST Hasan, RW Gable, S Knapp, DL Worthley

2026-09-10

Macrocyclization can enhance the selectivity of acyclic compounds toward structurally similar biological targets such as kinases. ..

Psychological distress and trajectories of sleep duration among Australian adolescents: a prospective cohort study

V Arya, S Munasinghe, S Sperandei, S Marjanovic, E Conroy, L Freebairn, A Page

2024-10-03

Objectives This study investigated the association between indicators of psychological distress and well-being and trajectories of..

Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes

DR Pierce, M McDonald, L Merone, L Becker, F Thompson, C Lewis, RYM Ryan, SF Hii, PA Zendejas-Heredia, RJ Traub, MA Field, T Rahman, J Croese, A Loukas, R McDermott, PR Giacomin

2023-12-01

The reduced prevalence of insulin resistance and type 2 diabetes in countries with endemic parasitic worm infections suggests a pr..

Matrix Selection for the Visualization of Small Molecules and Lipids in Brain Tumors Using Untargeted MALDI-TOF Mass Spectrometry Imaging

T Lu, L Freytag, VK Narayana, Z Moore, SJ Oliver, A Valkovic, B Nijagal, AL Peterson, DP de Souza, MJ McConville, JR Whittle, SA Best, S Freytag

2023-11-01

Matrix-assisted laser desorption/ionization mass spectrometry imaging allows for the study of metabolic activity in the tumor micr..

Severe NAD(P)HX Dehydratase (NAXD) Neurometabolic Syndrome May Present in Adulthood after Mild Head Trauma

NJ Van Bergen, K Gunanayagam, AM Bournazos, AS Walvekar, MO Warmoes, LN Semcesen, S Lunke, S Bommireddipalli, T Sikora, M Patraskaki, DL Jones, D Garza, D Sebire, S Gooley, CA McLean, P Naidoo, M Rajasekaran, DA Stroud, CL Linster, M Wallis

2023-02-01

We have previously reported that pathogenic variants in a key metabolite repair enzyme NAXD cause a lethal neurodegenerative condi..

Immune and genomic biomarkers of immunotherapy response in cancer of unknown primary

A Posner, T Sivakumaran, A Pattison, D Etemadmoghadam, N Thio, C Wood, K Fisher, S Webb, A Defazio, N Wilcken, B Gao, CS Karapetis, M Singh, IM Collins, G Richardson, C Steer, M Warren, N Karanth, A Fellowes, SB Fox

2023-01-31

Background Cancer of unknown primary (CUP) is a heterogeneous group of metastatic cancers where a primary tissue of origin (TOO) i..

Healthy breastfeeding infants consume different quantities of milk fat globule membrane lipids

AD George, MCL Gay, J Selvalatchmanan, F Torta, AK Bendt, MR Wenk, K Murray, ME Wlodek, DT Geddes

2021-09-01

The human milk fat globule membrane (MFGM) contains important lipids for growing infants. Anthropometric measurements, milk sample..

Prospects of using high-throughput proteomics to underpin the discovery of animal host–nematode interactions

T Wang, RB Gasser

2021-07-01

Parasitic nematodes impose a significant public health burden, and cause major economic losses to agriculture worldwide. Due to th..

An in-depth exploration of knowledge and beliefs associated with soda and diet soda consumption

C Miller, K Ettridge, M Wakefield, S Pettigrew, J Coveney, D Roder, S Durkin, G Wittert, J Martin, J Dono

2020-09-01

The need to reduce sugar-sweetened beverage (SSB) consumption is widely accepted, but whether artificially sweetened beverages (AS..

Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin

ST Ong, S Bajaj, MR Tanner, SC Chang, B Krishnarjuna, XR Ng, RAV Morales, MW Chen, D Luo, D Patel, S Yasmin, JJH Ng, Z Zhuang, HM Nguyen, A El Sahili, J Lescar, R Patil, SA Charman, EG Robins, JL Goggi

2020-08-14

We describe a cysteine-rich, membrane-penetrating, joint-targeting, and remarkably stable peptide, EgK5, that modulates voltage-ga..

Comorbid anxiety and irritability symptoms and their association with cognitive functioning in children with ADHD

N Read, M Mulraney, J McGillivray, E Sciberras

2020-08-01

Anxiety and irritability symptoms frequently co-occur in children with Attention-Deficit/Hyperactivity Disorder (ADHD). This study..

Early pregnancy vitamin d binding protein is independently associated with the development of gestational diabetes: A retrospective cohort study

M Fernando, SJ Ellery, D de Guingand, C Marquina, S Lim, CL Harrison, HJ Teede, N Naderpoor, A Mousa

2020-07-01

Background: Vitamin D-binding protein (VDBP) has been implicated in several adverse pregnancy outcomes either directly or indirect..

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley

2020-05-21

Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..

Harnessing stem cells and biomaterials to promote neural repair

KF Bruggeman, N Moriarty, E Dowd, DR Nisbet, CL Parish

2019-02-01

With the limited capacity for self-repair in the adult CNS, efforts to stimulate quiescent stem cell populations within discrete b..

Medical, demographic and psychological correlates of fear of cancer recurrence (FCR) morbidity in breast, colorectal and melanoma cancer survivors with probable clinically significant FCR seeking psychological treatment through the ConquerFear study.

Allan 'Ben' Smith, Louise Sharpe, Belinda Thewes, Jane Turner, Jemma Gilchrist, Joanna E Fardell, Afaf Girgis, Stephanie Tesson, Joseph Descallar, Melanie L Bell, Jane Beith, Phyllis Butow, ConquerFear Authorship Group

2018-12-01

PURPOSE: Despite the prevalence of fear of cancer recurrence (FCR), understanding of factors underlying clinically significant FCR..

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules

EK Schneider-Futschik, OKA Paulin, D Hoyer, KD Roberts, J Ziogas, MA Baker, J Karas, J Li, T Velkov

2018-05-11

The mucoid biofilm mode of growth of Pseudomonas aeruginosa (P. aeruginosa) in the lungs of cystic fibrosis patients makes eradica..

Health care costs associated with Australian tertiary inflammatory bowel disease care

B Jackson, D Con, R Ma, A Gorelik, D Liew, P De Cruz

2017-08-03

Introduction: We aimed to describe the total costs of illness for IBD patients and compare the costs of patients with active disea..

Effects of Neonatal Iron Feeding and Chronic Clioquinol Administration on the Parkinsonian Human A53T Transgenic Mouse

JL Billings, DJ Hare, M Nurjono, I Volitakis, RA Cherny, AI Bush, PA Adlard, DI Finkelstein

2016-03-16

Increased nigral iron (Fe) is a cardinal feature of Parkinson's disease, as is the accumulation of aggregates comprising α-synucle..